Demo Reel

Discovery of a small molecule disruptor of PAF1C in transcription pause-release & HIV latency reversal

SPT5 stabilization of promoter-proximal RNA polymerase II

Uncoupling histone H3K4 trimethylation from transcriprtion

SPT6 functions in transcriptional pause/release via PAF1C recruitment

Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia

Sickle-Cell Anemia

Symptoms of Anaphylaxis

Animation